Pregnyl (Human Chorionic Gonadotropin) injection — 10,000 USP units per vial — for licensed men’s health, TRT, and fertility practices. Prescription LH analog for maintaining testicular function during TRT, fertility preservation, and ovulation induction.
Pregnyl — Human Chorionic Gonadotropin (HCG) — is an injectable hormone that mimics the action of LH (luteinizing hormone), the signal the brain normally sends to the testes to produce testosterone. In men on testosterone replacement therapy, the brain stops sending LH because it detects enough testosterone in the bloodstream — which causes the testes to go dormant. Pregnyl keeps the testes active by providing that LH signal directly, bypassing the brain entirely. The result is maintained testicular function, preserved fertility, and prevention of the testicular atrophy that typically accompanies TRT. Rx only.
| Specification | Detail |
|---|---|
| Active ingredient | Human Chorionic Gonadotropin (HCG) |
| Strength | 10,000 USP Units per vial |
| Reconstitution | Bacteriostatic Water for Injection |
| Route | IM or subcutaneous |
| Storage | Refrigerate after reconstitution; protect from light |
| Prescription status | Rx only |
To get pricing, check availability, or place an order, click the Request a Quote button or contact our team directly. A valid medical or pharmacy license is required to purchase prescription and injectable products.
Pregnyl binds to the same receptor on Leydig cells in the testes that LH normally binds to — triggering testosterone production inside the testes and keeping those cells active. This matters because the testosterone produced inside the testes (intratesticular testosterone) is much higher in concentration than serum testosterone, and that high local concentration is what supports sperm production.
When a man starts TRT, his brain detects elevated testosterone and stops producing LH. Without LH, the Leydig cells stop working, intratesticular testosterone drops, testicular volume decreases, and sperm production declines. Pregnyl prevents this by acting directly at the testicular level — no need for the brain’s LH signal because Pregnyl provides the same stimulus.
Both are used to maintain testicular function during TRT. They work at different points in the hormonal system.
| Pregnyl (HCG) | Gonadorelin | |
|---|---|---|
| Where it acts | Testes directly | Pituitary gland |
| Depends on pituitary | No — bypasses it | Yes — pituitary must respond |
| LH and FSH both stimulated | LH effect only | Both LH and FSH |
| Best when | On TRT with suppressed pituitary | Off TRT or early in protocol |
| Estrogen effect | Can raise estradiol | Less direct estrogen effect |
For men already on TRT whose pituitary LH output is suppressed, Pregnyl is the more reliable option because it does not depend on pituitary responsiveness.
TRT and men’s health practices: The most common application. Men on testosterone replacement who want to maintain testicular size, preserve fertility, or maintain the physiological processes that depend on intratesticular testosterone use Pregnyl as the standard TRT adjunct. Patients increasingly arrive already aware of the testicular atrophy risk from TRT and asking specifically about fertility-preserving options.
Hormone optimization practices: Comprehensive hormone protocols that go beyond testosterone monotherapy incorporate Pregnyl to maintain testicular activity alongside serum testosterone optimization.
Fertility and reproductive medicine practices: FDA-approved ovulation induction in anovulatory women following gonadotropin pretreatment. Also used in male infertility management where testicular stimulation and sperm production support are the clinical goals.
Post-TRT restart protocols: Men discontinuing testosterone therapy need their HPG axis to recover. Pregnyl is used in restart protocols to maintain endogenous testosterone production while the brain and pituitary recalibrate.
Gonadorelin Peptide Injection — Gonadorelin stimulates the pituitary to release LH and FSH endogenously, maintaining HPG axis activity. Pregnyl acts directly at the testicular level, bypassing the pituitary. Some practices use both in comprehensive protocols; others choose one based on patient presentation and clinical goals.
Anastrozole 1mg Tablets — Pregnyl stimulates Leydig cell aromatase activity, which can increase estradiol production in men. Practices running Pregnyl alongside testosterone protocols should monitor estradiol closely and have anastrozole available for estrogen management when indicated.
Tadalafil Tablets — PDE5 inhibitor for erectile function support. Tadalafil and Pregnyl address different aspects of men’s sexual and hormonal health and are frequently prescribed together in comprehensive TRT protocols.
DIM (Diindolylmethane) — Estrogen metabolism support for practices managing estradiol alongside Pregnyl and testosterone therapy. DIM supports phase II estrogen clearance, complementing anastrozole’s upstream aromatase inhibition.
Estradiol elevation: Pregnyl increases aromatase activity in the testes, which can raise estradiol in men. Monitor estradiol with a sensitive assay when initiating or adjusting Pregnyl dose. Anastrozole may be needed.
Androgen-sensitive tumors: Stimulating testosterone production is contraindicated in patients with androgen-sensitive tumors including prostate cancer. Evaluate prostate health before initiating Pregnyl in older male patients.
Ovarian hyperstimulation syndrome (OHSS) in women: In women using Pregnyl for ovulation induction, OHSS is a risk — sudden ovarian enlargement, pelvic pain, bloating, and in severe cases fluid accumulation and electrolyte changes. Pregnyl for ovulation induction should be administered by providers experienced in fertility management. This risk does not apply to standard men’s health use.
Multiple births in women: Ovulation induction protocols carry an increased risk of multiple gestations. Counsel female patients accordingly.
Leydig cell desensitization: Very high Pregnyl doses used over extended periods can desensitize Leydig cell receptors. Keep doses within clinically appropriate ranges and monitor testicular response.
Hypersensitivity: Allergic reactions including anaphylaxis have been reported. Have emergency treatment available.
For use by or on the order of a licensed healthcare provider.
How do I order, and what quantities are available?
Contact our team directly to place an order or request a quote. We supply a range of quantities depending on the product — reach out for current availability, lead times, and volume pricing. A valid medical license is required to purchase prescription and injectable products.
Why do men on TRT need Pregnyl?
When a man starts TRT, his brain detects elevated testosterone and stops producing LH — the signal that tells the testes to work. Without LH, the testes stop producing testosterone internally, shrink in size, and sperm production declines. Pregnyl delivers the same signal as LH directly to the testes, keeping them active even while the brain’s own signal is suppressed by TRT.
What is the difference between Pregnyl and Gonadorelin for TRT support?
Gonadorelin stimulates the pituitary to produce LH and FSH — it works at the brain level. Pregnyl bypasses the brain entirely and stimulates the testes directly. For men already on TRT whose pituitary LH output is suppressed, Pregnyl is more reliable because it does not depend on pituitary responsiveness.
Does Pregnyl affect estrogen levels in men?
Yes. Pregnyl increases testosterone production in the testes, which also increases the conversion of testosterone to estradiol. Men on Pregnyl alongside TRT should have estradiol monitored and may need anastrozole if levels rise above the optimal range.
Is a prescription required?
Yes. Pregnyl (HCG) injection is Rx only, available exclusively to licensed healthcare providers and medical practices.
For use by or on the order of a licensed healthcare provider.
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