Tadalafil tablets 5mg, 10mg, and 20mg — generic Cialis for men’s health and TRT practices. ED treatment with up to 36 hours of effect, a daily low-dose option, and a dual FDA approval covering both erectile dysfunction and BPH.
Tadalafil — generic Cialis — is the most versatile prescription ED medication available. Its up to 36-hour duration of effect is the longest of any PDE5 inhibitor, and it is the only ED medication with a daily low-dose option (5mg) that eliminates the need to plan around a pill. It also carries a dual FDA approval covering both erectile dysfunction and benign prostatic hyperplasia (BPH) — making it practical for men whose urinary symptoms and sexual health concerns overlap, which is a common presentation in men’s health and urology-adjacent practices. Available in 5mg, 10mg, and 20mg.
| Strength | Primary Protocol | Clinical Use |
|---|---|---|
| 5 mg | Daily | ED with spontaneity; BPH symptom management; concurrent ED + BPH |
| 10 mg | As-needed | Standard starting dose for on-demand use |
| 20 mg | As-needed | Maximum dose; for patients with insufficient response to 10mg |
Storage: Room temperature, away from excess heat and moisture.
Prescription status: Rx only. Available to licensed healthcare providers and medical practices only.
Legere supplies licensed medical practices with a range of quantities to fit your volume needs. To get pricing, check availability, or place an order, click Request a Quote above or contact our team directly. A valid medical or pharmacy license is required to purchase prescription and injectable products.
During sexual stimulation, nitric oxide released in the penis activates a chain reaction that relaxes smooth muscle and increases blood flow into erectile tissue. Tadalafil works by blocking PDE5, the enzyme that breaks down the chemical (cGMP) that keeps that process going. When PDE5 is blocked, blood flow to the penis continues longer in response to sexual stimulation — producing stronger, more sustained erections.
Tadalafil does not cause erections on its own. Sexual stimulation is required. What it does is make the natural response to stimulation more reliable and sustained.
Its long duration of action comes from a half-life of approximately 17.5 hours — roughly three to four times longer than sildenafil. A single as-needed dose stays active through the following day. The daily 5mg dose maintains consistent tadalafil levels throughout the week, effectively removing the need to plan around timing.
| Strength | Primary Use |
|---|---|
| 5mg daily | Daily dosing protocol for spontaneous sexual activity and/or BPH symptom management |
| 10mg as needed | Standard starting dose for as-needed use |
| 20mg as needed | Step-up for insufficient response at 10mg; maximum as-needed dose |
Both are PDE5 inhibitors. The right choice depends on the patient’s lifestyle and clinical picture.
| Tadalafil (Generic Cialis) | Sildenafil (Generic Viagra) | |
|---|---|---|
| Duration | Up to 36 hours | 4-6 hours |
| Daily dosing option | Yes — 5mg | No |
| BPH indication | Yes | No |
| Food interaction | Minimal | High-fat meals delay onset |
| Best for | Spontaneity; daily dosing; BPH overlap | Event-specific timing; shorter window preferred |
Practices that stock both give patients a real choice based on how they live — not just which medication the practice happens to carry.
Men’s health and TRT practices: Tadalafil is a natural addition to any men’s health formulary. Men on TRT who restore testosterone but still experience vascular erectile dysfunction benefit from PDE5 inhibitor therapy — and many prefer tadalafil’s longer window and daily dosing option for the spontaneity it provides.
Urology-adjacent practices: The dual BPH indication is clinically significant in urology-adjacent settings. Men with both BPH and ED — a common combination in men over 50 — can address both conditions with a single prescription. The daily 5mg dose is approved for both indications simultaneously.
Sexual health and integrative practices: Comprehensive sexual health programs that address both hormonal and vascular contributors to erectile function. Tadalafil addresses the vascular side; TRT and other hormone tools address the hormonal side.
DHEA 25mg Capsules — Adrenal hormone precursor support for practices combining foundational hormone support with tadalafil’s PDE5 mechanism — addressing hormonal and vascular contributors to sexual health simultaneously.
DIM (Diindolylmethane) — Estrogen metabolism support for TRT practices. As testosterone is initiated or adjusted, DIM supports healthy estrogen clearance while tadalafil supports erectile function — complementary components of a comprehensive men’s health protocol.
Gonadorelin Peptide Injection — HPG axis support for TRT practices. Gonadorelin maintains endogenous hormone production alongside testosterone therapy; tadalafil addresses erectile function. A common combination in comprehensive men’s health protocols.
Sildenafil Tablets (Generic Viagra) — Carrying both tadalafil and sildenafil gives practices coverage for different patient preferences. Tadalafil for daily dosing, spontaneity, and BPH overlap; sildenafil for shorter-duration, event-specific use. Patients appreciate having a choice rather than being defaulted to one option.
Pregnyl (HCG) Injection — For practices running comprehensive men’s health protocols. Pregnyl supports testicular function and hormone production; tadalafil addresses erectile function. Complementary tools for different aspects of male sexual health.
Nitrate contraindication — absolute: Tadalafil is contraindicated with all nitrate medications — nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, and nitrate-containing recreational drugs (“poppers”). The combination causes severe, potentially fatal drops in blood pressure. This is the most critical safety check before prescribing.
Riociguat: contraindicated. Do not use concurrently.
Cardiovascular screening: Sexual activity increases cardiac demand. Screen cardiovascular risk before prescribing. Use with caution in hypotension, uncontrolled hypertension, recent MI or stroke, or unstable angina.
Alpha-blocker interaction: Concurrent use with alpha-blockers can cause significant blood pressure drops. Start at the lowest tadalafil dose and monitor. This interaction is particularly relevant in men being treated for BPH with an alpha-blocker.
CYP3A4 interactions: Tadalafil is metabolized by CYP3A4. Strong inhibitors (ketoconazole, ritonavir) increase tadalafil exposure and may require dose reduction. Strong inducers (rifampin) reduce efficacy.
Back and muscle pain: More common with tadalafil than other PDE5 inhibitors due to PDE11 activity. Usually mild and resolves within 12-48 hours. Counsel patients that this is a known side effect rather than a sign of a serious problem.
Hearing and vision changes: Sudden decrease or loss of hearing or vision has been reported with PDE5 inhibitors. Instruct patients to discontinue and seek immediate care if this occurs.
How do I order, and what quantities are available?
Contact our team directly to place an order or request a quote. We supply a range of quantities depending on the product — reach out for current availability, lead times, and volume pricing. A valid medical license is required to purchase prescription and injectable products.
What is the difference between daily tadalafil and as-needed tadalafil?
The as-needed doses (10mg or 20mg) are taken about an hour before sexual activity and work for up to 36 hours. The daily 5mg dose is taken every day regardless of planned sexual activity — it maintains consistent levels so there is no timing window to manage. Daily dosing is also approved for BPH symptom management. The right choice depends on frequency of sexual activity and whether BPH is part of the clinical picture.
What is the difference between tadalafil and sildenafil?
Both treat ED through the same mechanism. Tadalafil lasts up to 36 hours and has a daily dosing option; sildenafil lasts 4-6 hours with no daily option. Tadalafil is also approved for BPH; sildenafil is not. High-fat meals significantly delay sildenafil’s onset but have minimal effect on tadalafil. Many practices carry both to match patient preference.
Can tadalafil be prescribed alongside testosterone therapy?
Yes. TRT and tadalafil address different aspects of male sexual health — testosterone supports libido and hormonal drive; tadalafil supports the vascular erectile mechanism. They work through different pathways. The primary prescribing safety check for combined use is nitrates and alpha-blockers, not testosterone.
Is a prescription required?
Yes. Tadalafil is Rx only, available exclusively to licensed healthcare providers and medical practices.
This is a compounded medication. Compounded drugs are not FDA-approved and have not been evaluated by the FDA for safety, efficacy, or quality. This product is available by prescription only and is intended for use by or on the order of a licensed healthcare provider.
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