Diindolylmethane (DIM) at 113mg supports healthy estrogen metabolism in both men and women, helping the body process estrogen more efficiently. A natural pairing with DHEA and testosterone protocols for practices offering comprehensive hormone balance support.
DIM (Diindolylmethane) is a compound derived from cruciferous vegetables that supports healthy estrogen metabolism — helping the body convert estrogen into its more favorable metabolites rather than accumulating less desirable forms. It’s one of the most commonly recommended hormone-adjacent supplements in TRT, BHRT, and functional medicine protocols, particularly for practices managing estrogen balance in male testosterone patients and perimenopausal or postmenopausal female patients.
Legere’s DIM formula goes beyond a single-ingredient approach with two proprietary supporting blends — Estro Pro Blend and Ultra Phyto-Support — adding antioxidant, liver support, and adaptogenic ingredients that reinforce DIM’s hormonal metabolism mechanism.
Each capsule contains:
| Ingredient | Amount |
|---|---|
| Diindolylmethane (DIM) | 113 mg |
| Ultra Phyto-Support Blend | 210 mg |
| Estro Pro Blend | 100 mg |
Ultra Phyto-Support Blend (210mg): Ceylon Cinnamon, Parsley, Fermented Cordyceps, Beet, American Ginseng, Chinese Salvia, and Fennel — a botanical blend supporting comprehensive wellness and metabolic balance alongside hormone support.
Estro Pro Blend (100mg): Organic Turmeric, Milk Thistle, and Green Tea Extract — supporting antioxidant protection and liver detoxification pathways involved in healthy estrogen clearance.
Suggested use: As directed by the ordering provider.
Most DIM supplements are single-ingredient. Legere’s version adds two supporting blends with a specific clinical rationale: the Estro Pro Blend directly supports liver detoxification, the primary pathway through which the body clears processed estrogen metabolites. Milk Thistle supports hepatic function, Turmeric supports healthy inflammatory response, and Green Tea Extract adds antioxidant activity — all relevant to how effectively the body completes the estrogen metabolism cycle that DIM initiates.
Estrogen management in TRT patients: When testosterone converts to estrogen via aromatase, male TRT patients can accumulate elevated estrogen levels — a common cause of water retention, mood changes, and reduced protocol effectiveness. DIM supports the body’s ability to process and clear estrogen metabolites through the 2-hydroxylation pathway, supporting more favorable estrogen balance alongside testosterone therapy.
BHRT and women’s hormone balance: In perimenopausal and postmenopausal women, the ratio of estrogen metabolites matters as much as total estrogen levels. DIM supports conversion toward 2-hydroxyestrogen metabolites, associated with favorable hormonal balance outcomes in BHRT protocols.
Hormone detoxification support: The Estro Pro Blend’s liver support components address the downstream detoxification step — once DIM shifts estrogen metabolism, the liver must clear the resulting metabolites efficiently. This makes the full formula more clinically complete than DIM alone.
DHEA 25mg — The most natural hormone supplement pairing on the site. DHEA is the upstream precursor feeding testosterone and estrogen production; DIM supports healthy metabolism of the estrogen produced downstream. Together they address both sides of hormone optimization for male and female patients.
Gonadorelin Peptide Injection — For TRT practices combining injectable hormone support with oral hormone balance supplements — Gonadorelin maintains HPG axis function while DIM manages estrogen metabolism at the peripheral level.
Is DIM appropriate for both male and female patients?
Yes. DIM supports healthy estrogen metabolism in both men and women, making it relevant across TRT, BHRT, men’s health, and women’s health hormone protocols.
What makes this DIM formula different from single-ingredient DIM supplements?
In addition to DIM at 113mg, this formula includes the Estro Pro Blend (Turmeric, Milk Thistle, Green Tea Extract) for liver detoxification support and the Ultra Phyto-Support Blend for comprehensive botanical wellness. The liver support is clinically meaningful — efficient estrogen clearance requires both healthy metabolism and healthy hepatic detoxification.
What other products pair well with DIM?
DHEA is the most common pairing for TRT and BHRT protocols. Practices building comprehensive injectable and oral hormone protocols often add Gonadorelin Peptide Injection alongside DIM.
Can DIM be private labeled under our practice brand?
Yes. Contact our team for minimum order quantities and packaging options.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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