Vitamin B6 at 85mg/mL supports amino acid metabolism, neurotransmitter synthesis (serotonin, dopamine, GABA), and red blood cell production. Available as a compounded alternative during periods of commercial drug shortage.
Pyridoxine hydrochloride (Vitamin B6) is an essential water-soluble B-vitamin that the body cannot produce on its own. Once absorbed, it converts to its active form, pyridoxal phosphate (PLP), which participates in over 100 enzymatic reactions including amino acid metabolism, neurotransmitter synthesis, hemoglobin production, and immune function. Injectable pyridoxine delivers B6 directly into the bloodstream, bypassing any absorption limitations at the gut level and providing the rapid systemic availability needed in clinical settings.
Pyridoxine injection has experienced extended commercial drug shortages. Compounded pyridoxine from a licensed pharmacy offers a clinical alternative when commercially manufactured product is unavailable.
| Specification | Detail |
|---|---|
| Active ingredient | Pyridoxine Hydrochloride (Vitamin B6) |
| Concentration | 85 mg/mL |
| Route | IV, IM, or SQ |
| Storage | Controlled room temperature; protect from light |
Once converted to pyridoxal phosphate (PLP), Vitamin B6 supports:
Amino acid metabolism: PLP is a required coenzyme for the breakdown and synthesis of amino acids, the building blocks of proteins throughout the body.
Neurotransmitter synthesis: PLP is required for the synthesis of serotonin, dopamine, and GABA, neurotransmitters that regulate mood, sleep, and neurological function.
Hemoglobin production: B6 is required for hemoglobin synthesis, the oxygen-carrying protein in red blood cells. Deficiency can contribute to certain forms of anemia.
Immune function: B6 supports the production of lymphocytes and the body’s inflammatory response, contributing to healthy immune system function.
Homocysteine metabolism: Alongside B12 and folate, B6 is a required coenzyme for converting homocysteine to cysteine, supporting cardiovascular health.
Most people acquire sufficient B6 through diet, but certain conditions and medications can cause or contribute to deficiency:
Pyridoxine Injection is commonly used in:
Dosage should be determined by the ordering provider based on the patient’s B6 levels, clinical indication, and therapeutic goals. Consult current clinical guidelines and state prescribing requirements.
High-stakes drug interactions requiring provider review:
Common side effects at standard doses: Pyridoxine is generally well-tolerated at recommended doses. With prolonged high-dose use, sensory neuropathy (numbness, tingling in arms and legs), headache, nausea, and drowsiness have been reported.
Seek immediate attention for: Rash, itching, swelling, severe dizziness, or difficulty breathing, which may indicate an allergic reaction.
As a compounded Rx product, Pyridoxine Injection has not been evaluated by the FDA for safety, efficacy, or quality. Administer only under the supervision of a licensed healthcare provider in accordance with current clinical and state regulatory guidelines.
Practices offering Pyridoxine Injection often combine it with Methylcobalamin B12 Injection, Hydroxocobalamin B12 Injection, Ascorbic Acid Injection, and Magnesium Chloride Injection as part of a comprehensive B-vitamin and micronutrient IV protocol.
Is a prescription required to order Pyridoxine Injection?
Yes. Pyridoxine Injection is a compounded Rx product dispensed exclusively to licensed healthcare providers and medical practices. It is not available for direct patient purchase.
Why is compounded pyridoxine injection available?
Pyridoxine injection has experienced extended commercial drug shortages. Compounded pyridoxine from a licensed pharmacy provides a clinical alternative when the commercially manufactured product is unavailable or in limited supply.
What is the concentration and route of administration?
85mg/mL, available for IV, IM, or SQ administration. Route and dosing are determined by the ordering provider’s clinical protocol.
What are the most important drug interactions providers should know about?
Pyridoxine can reduce the effectiveness of altretamine chemotherapy when combined with cisplatin, and can significantly reduce the effectiveness of levodopa in Parkinson’s patients. A full medication review is required before initiating.
What other injectables pair well with Pyridoxine?
Providers often combine Pyridoxine with Methylcobalamin B12, Hydroxocobalamin B12, Ascorbic Acid, and Magnesium Chloride as part of a comprehensive B-vitamin and micronutrient IV protocol.
This is a compounded medication. Compounded drugs are not FDA-approved and have not been evaluated by the FDA for safety, efficacy, or quality. This product is available by prescription only and is intended for use by or on the order of a licensed healthcare provider.
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