Hydroxocobalamin Injection

A naturally occurring, long-acting form of Vitamin B12 at 2mg/mL with a longer half-life than cyanocobalamin. Supports energy metabolism, myelin health, and red blood cell production via IV, IM, or SQ.

Hydroxocobalamin Injection: Naturally Occurring B12 at 2mg/mL

Hydroxocobalamin is the naturally occurring form of B12 with a longer half-life than cyanocobalamin, meaning it stays active in the body longer per dose, with no synthetic conversion required. For practices building a B12 protocol, it’s the longer-lasting, naturally sourced option that converts to both active B12 forms in the body.

Formula

SpecificationDetail
Concentration2 mg/mL
RouteIV, IM, or SQ
StorageRoom temperature; protect from light

Hydroxocobalamin vs. Other B12 Forms

FormKey Feature
HydroxocobalaminNaturally occurring; longest half-life; converts to both active forms
MethylcobalaminActive neurological form; direct methylation support
CyanocobalaminSynthetic standard; lowest cost; requires conversion

Why Practices Add Hydroxocobalamin to Their Menu

Longer half-life: Stays active in the body longer than cyanocobalamin — supports sustained B12 levels between doses.

Natural form: Converts to both active B12 forms (methylcobalamin and adenosylcobalamin) directly in the body — no synthetic steps required.

Energy metabolism: Required for converting fats and carbohydrates into cellular energy — reduces B12 deficiency-related fatigue.

Nerve health: Supports myelin synthesis and maintenance — the protective nerve coating that declines with B12 deficiency.

Who It’s For

  • Medical weight loss and metabolic health clinics incorporating B12 as a metabolic support component
  • IV therapy and wellness clinics building out a comprehensive B-vitamin injectable menu
  • Primary care and internal medicine providers managing B12 deficiency in high-risk patient populations
  • Integrative and functional medicine providers supporting homocysteine metabolism and neurological health

Pairs Well With

Practices offering Hydroxocobalamin B12 Injection often combine it with Lipo-Mino-C, Biotin Injection, Ascorbic Acid Injection, and Glutathione Injection as part of a comprehensive IV nutrition and wellness protocol.

FAQ

Is a prescription required? Yes. Available exclusively to licensed healthcare providers and medical practices.

What is the concentration and route? 2mg/mL, for IV, IM, or SQ administration.

What is the most important contraindication? Leber’s disease — B12 can accelerate optic nerve deterioration. Hypokalemia is also a contraindication; monitor potassium during treatment.

What pairs well with Hydroxocobalamin? Lipo-Mino-C, Biotin, Ascorbic Acid, and Glutathione as part of a complete IV nutrition and wellness protocol.

This is a compounded medication. Compounded drugs are not FDA-approved and have not been evaluated by the FDA for safety, efficacy, or quality. This product is available by prescription only and is intended for use by or on the order of a licensed healthcare provider.

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