NAD+ Injection delivers the active coenzyme Nicotinamide Adenine Dinucleotide at 100mg/mL directly into the bloodstream — supporting cellular energy production, DNA repair, sirtuin activation, and mitochondrial health. The most direct NAD+ delivery option in the longevity injectable lineup.
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every living cell and involved in hundreds of metabolic reactions. It is the essential electron carrier in cellular energy production and a required substrate for the enzymes — sirtuins and PARPs — that govern DNA repair and cellular stress response. NAD+ levels decline with age, a process now recognized as a central driver of reduced mitochondrial function, impaired DNA repair capacity, and declining cellular resilience. Injectable NAD+ delivers the active coenzyme directly into the bloodstream at 100mg/mL — the most direct route available for restoring NAD+ levels.
| Specification | Detail |
|---|---|
| Active ingredient | Nicotinamide Adenine Dinucleotide (NAD+) |
| Concentration | 100 mg/mL |
| Route | IV, IM, or SQ |
| Storage | Refrigerate; protect from light |
Both products raise NAD+ levels — but through different mechanisms and with different delivery profiles:
| NAD+ Injection | Niagen® (NR) Injection | |
|---|---|---|
| Compound | NAD+ (active coenzyme directly) | Nicotinamide Riboside (NR — precursor) |
| Mechanism | Directly raises blood NAD+ | Converts to NAD+ via NRK1/NRK2 pathway |
| Onset | Immediate — no conversion needed | Requires metabolic conversion |
| Concentration | 100 mg/mL | 100 mg/mL |
| Volume | Confirm with account rep | 5mL |
| Route | IV, IM, or SQ | IV, IM, or SQ |
Choose NAD+ Injection when immediate, direct NAD+ delivery is the clinical priority — IV protocols, acute NAD+ repletion, or patients where conversion efficiency is a concern.
Choose Niagen® (NR) Injection when a research-validated, patent-protected NR precursor is preferred and the conversion pathway is intact and efficient.
Many longevity practices carry both — using IV NAD+ for acute repletion sessions and NR for ongoing maintenance protocols.
Cellular energy production: NAD+ is the primary electron carrier in the mitochondrial electron transport chain — the process that converts nutrients into ATP. Declining NAD+ directly reduces the efficiency of this process, contributing to the fatigue, reduced endurance, and cognitive fog associated with aging.
DNA repair: NAD+ is a required substrate for PARP enzymes, which detect and repair DNA damage from oxidative stress, UV exposure, and normal metabolic activity. Adequate NAD+ supports the DNA repair capacity that declines with age.
Sirtuin activation: Sirtuins are NAD+-dependent enzymes associated with mitochondrial biogenesis, inflammatory regulation, and cellular stress resistance. Without adequate NAD+, sirtuin activity declines regardless of other longevity interventions.
Mitochondrial biogenesis: Through sirtuin and PARP activation, NAD+ supports the growth and maintenance of mitochondria — the organelles responsible for cellular energy production and metabolic function.
Cognitive support: NAD+ supports neuronal energy metabolism and neuroprotective processes. Research suggests that adequate NAD+ levels support mental clarity, concentration, and cognitive resilience.
Niagen® (NR) Injection — For practices offering both: IV NAD+ for acute repletion sessions, Niagen® for ongoing maintenance between sessions. The two protocols complement rather than duplicate each other.
CoQ10 Injection — CoQ10 drives the electron transport chain alongside NAD+. Together they support the complete mitochondrial energy production pathway from electron carrier to ATP synthesis.
Glutathione Injection — Adds cellular antioxidant protection alongside NAD+’s DNA repair and sirtuin activation roles — a comprehensive longevity protocol pairing.
NAD+ is generally well-tolerated. The most common side effects are infusion-rate dependent and typically transient:
Common side effects (particularly with IV, often rate-dependent):
Practical guidance: Starting with a slower IV infusion rate and titrating up based on patient tolerance significantly reduces the incidence of side effects. Many providers start patients at lower doses and build up over successive sessions.
Known interactions: NAD+ may interact with medications affecting NAD+ metabolism including some chemotherapy agents. Full medication review recommended before initiating.
Pregnancy and breastfeeding: Use with caution; consult clinical specialists before initiating.
Refrigerate: Unlike most injectables in the catalog, NAD+ requires refrigeration. Do not store at room temperature.
As a compounded Rx product, NAD+ Injection has not been evaluated by the FDA for safety, efficacy, or quality. Administer only under the supervision of a licensed healthcare provider in accordance with current clinical and state regulatory guidelines.
Is a prescription required to order NAD+ Injection?
Yes. Available exclusively to licensed healthcare providers and medical practices.
What is the concentration and route?
100mg/mL, for IV, IM, or SQ administration. Refrigerate — this product requires cold storage.
How does NAD+ Injection differ from Niagen® (NR) Injection?
NAD+ Injection delivers the active coenzyme directly — no conversion needed. Niagen® delivers Nicotinamide Riboside, a precursor that converts to NAD+ via the NRK1/NRK2 pathway. NAD+ Injection provides more immediate delivery; Niagen® is a research-validated precursor option. Many longevity practices carry both for different clinical contexts.
What causes the flushing or tingling some patients experience during infusion?
These are rate-dependent effects common with IV NAD+ infusion. Slowing the infusion rate typically resolves them. Starting at a lower dose and titrating up over successive sessions significantly reduces the incidence in most patients.
This is a compounded medication. Compounded drugs are not FDA-approved and have not been evaluated by the FDA for safety, efficacy, or quality. This product is available by prescription only and is intended for use by or on the order of a licensed healthcare provider.
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