NAD+ injection for IV therapy, longevity, and wellness practices. Prescription coenzyme for cellular energy, brain health, and anti-aging IV protocols.
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme present in every cell in the body, essential for energy production, DNA repair, and cellular function. Levels decline with age, and intravenous NAD+ administration delivers it directly into the bloodstream — bypassing the absorption limitations of oral supplements to achieve much higher cellular availability. Available in 100mg/mL and 200mg/mL concentrations for licensed IV therapy, longevity, and wellness practices. Rx only.
| Specification | 100 mg/mL | 200 mg/mL |
|---|---|---|
| Active ingredient | Nicotinamide Adenine Dinucleotide (NAD+) | Nicotinamide Adenine Dinucleotide (NAD+) |
| Concentration | 100 mg/mL | 200 mg/mL |
| Route | IV, IM, or SQ | IV, IM, or SQ |
| Storage | Refrigerate; protect from light | Refrigerate; protect from light |
| Best for | Standard IV infusion protocols; initiation dosing | High-dose IV protocols; IM/SQ volume efficiency; intensive loading sessions |
100mg/mL is the standard concentration for IV NAD+ infusion protocols — appropriate for most longevity, wellness, and anti-aging IV programs and for patients new to NAD+ therapy.
200mg/mL is the high-dose option for practices running intensive NAD+ protocols. The doubled concentration allows delivery of a higher total NAD+ dose in the same infusion volume, or the same dose in half the volume — an advantage for IM and SQ routes where injection volume matters, and for IV practices offering 400–500mg high-dose loading sessions.
| Specification | Detail |
|---|---|
| Active ingredient | Nicotinamide Adenine Dinucleotide (NAD+) |
| Available concentrations | 100 mg/mL and 200 mg/mL |
| Route | IV infusion |
| Infusion rate | Slow IV infusion — must be given slowly to minimize side effects |
| Storage | Refrigerate; protect from light |
| Prescription status | Rx only |
Legere supplies licensed medical practices with a range of quantities to fit your volume needs. To get pricing, check availability, or place an order, click Request a Quote above or contact our team directly. A valid medical or pharmacy license is required to purchase prescription and injectable products.
NAD+ sits at the center of cellular energy metabolism. It is the key molecule in the process that converts nutrients from food into ATP — the energy currency that every cell uses to function. Without adequate NAD+, this process becomes less efficient.
Beyond energy production, NAD+ activates a family of proteins called sirtuins that regulate DNA repair, inflammation control, and cellular stress responses — processes closely linked to how cells age. It also plays a central role in repairing DNA damage, which accumulates over time and contributes to aging and cellular dysfunction.
NAD+ levels decline naturally with age and are further depleted by alcohol consumption, poor sleep, chronic stress, and illness. IV administration is the most direct way to replenish them — oral NAD+ has significant absorption limitations that IV delivery bypasses entirely.
| 100 mg/mL | 200 mg/mL | |
|---|---|---|
| Best for | Standard NAD+ protocols; new patients; practices starting with lower doses | High-dose protocols; experienced patients; practices targeting aggressive longevity or recovery applications |
| Volume per dose | Higher volume at equivalent dose | Smaller volume at equivalent dose — useful for shorter infusion times |
| Infusion rate | Still must be administered slowly | Must be administered slowly — higher concentration does not reduce the need for slow infusion |
Many practices stock both concentrations to accommodate different protocol designs and patient preferences.
NAD+ must be infused slowly. Administering it too fast causes a characteristic set of side effects — chest tightness, shortness of breath, nausea, and a flushing sensation — that are uncomfortable but not dangerous and resolve when the infusion rate is slowed. These symptoms are not allergic reactions; they are rate-dependent effects of NAD+ reaching the heart and lungs too quickly.
Standard protocols use normal saline as the carrier and run the infusion over 2-4 hours for a typical dose. Patient tolerance improves with repeated infusions. New patients should always start at the lower end of the rate range.
IV therapy and longevity clinics: NAD+ is one of the highest-value infusions in the IV therapy menu. Patients seeking anti-aging, energy, and cognitive health benefits are willing to invest in longer infusion sessions — NAD+ protocols typically run 2-4 hours and are priced accordingly. Practices that offer NAD+ as a premium add-on or standalone infusion are able to serve the growing longevity market.
Functional and integrative medicine practices: NAD+ fits naturally into functional medicine protocols addressing cellular aging, mitochondrial function, and metabolic health. Practices that take a root-cause approach to aging and energy depletion find NAD+ IV a clinically meaningful addition to their toolkit.
Recovery and performance practices: Athletes, executives, and high-performance patients seeking accelerated recovery, improved mental clarity, and sustained energy. NAD+ IV is positioned as both a recovery tool and a performance optimization protocol in these settings.
Addiction recovery programs: NAD+ IV has been used in addiction recovery settings to support neurological repair and reduce withdrawal-associated fatigue and cravings. This is an off-label application but one with a growing body of clinical interest.
Niagen® (NR) Injection — For practices offering both: IV NAD+ for acute repletion sessions, Niagen® for ongoing maintenance between sessions. The two protocols complement rather than duplicate each other.
CoQ10 Injection — CoQ10 drives the electron transport chain alongside NAD+. Together they support the complete mitochondrial energy production pathway from electron carrier to ATP synthesis.
Glutathione Injection — The body’s master antioxidant, frequently combined with NAD+ in longevity and cellular health protocols. Glutathione is typically administered as a separate push at the end of the infusion rather than mixed directly with NAD+.
0.9% Sodium Chloride IV Bag — Normal saline is the standard carrier solution for NAD+ infusion. NAD+ is diluted into saline and administered over 2-4 hours. These two are always used together.
Ascorbic Acid (Vitamin C) Injection — Vitamin C is a common add-on to NAD+ infusion protocols for additional antioxidant support alongside NAD+’s cellular repair mechanisms.
B-Complex Injection (Vita-Complex) — B vitamins support the same energy metabolism pathways that NAD+ is central to. Adding B-complex to an NAD+ protocol provides comprehensive metabolic support.
Slow infusion rate is mandatory: The most important administration rule for NAD+. Infusing too fast causes chest tightness, shortness of breath, nausea, and flushing. These are rate-dependent side effects, not allergic reactions. Slow the infusion if symptoms occur — they resolve quickly when the rate is reduced. Establish a standard protocol with a conservative rate for new patients.
Flushing and discomfort: Even at appropriate rates, some patients experience mild flushing, warmth, or a sense of pressure in the chest. This is a known NAD+ effect and is generally well-tolerated when patients are counseled in advance. Set expectations before the first infusion.
No established long-term safety data for high-dose IV use: NAD+ is a naturally occurring molecule and is generally considered safe. However, long-term clinical data on high-dose repeated IV administration is still developing. Follow current clinical guidance and monitor patients on ongoing protocols.
Pregnancy and breastfeeding: Insufficient safety data for IV NAD+ in pregnancy or while breastfeeding. Avoid unless clearly indicated and under appropriate medical oversight.
This is a compounded medication. Compounded drugs are not FDA-approved and have not been evaluated by the FDA for safety, efficacy, or quality. This product is available by prescription only and is intended for use by or on the order of a licensed healthcare provider.
How do I order, and what quantities are available?
Contact our team directly to place an order or request a quote. We supply a range of quantities depending on the product — reach out for current availability, lead times, and volume pricing. A valid medical license is required to purchase prescription and injectable products.
Why does IV NAD+ work better than oral supplements?
Oral NAD+ precursors (NMN, NR) have to survive digestion and absorption before reaching the bloodstream, which limits how much actually gets into cells. IV NAD+ bypasses that process entirely — it goes directly into the bloodstream at a known concentration. The result is substantially higher cellular availability than any oral supplement can reliably achieve.
Why do some patients feel chest tightness during NAD+ infusions?
This is a rate-dependent effect, not an allergic reaction. When NAD+ reaches the heart and lungs too quickly, it produces a characteristic sensation of chest tightness, shortness of breath, and sometimes nausea. Slowing the infusion rate resolves these symptoms quickly. Most patients tolerate NAD+ well when the rate is managed correctly, and tolerance typically improves with repeated sessions.
What is the difference between 100mg/mL and 200mg/mL NAD+?
Both contain the same active ingredient. The 200mg/mL concentration delivers twice the dose in the same volume — useful for practices targeting higher-dose protocols or wanting to reduce the total infusion volume at equivalent doses. Both require slow administration. Many practices stock both to accommodate different protocol designs.
Is a prescription required?
Yes. NAD+ injection is Rx only, available exclusively to licensed healthcare providers and medical practices.
This is a compounded medication. Compounded drugs are not FDA-approved and have not been evaluated by the FDA for safety, efficacy, or quality. This product is available by prescription only and is intended for use by or on the order of a licensed healthcare provider.
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