ChromaDex’s proprietary Nicotinamide Riboside at 100mg/mL raises NAD+ levels to support sirtuin activation, DNA repair, and mitochondrial health. A research-backed cornerstone of longevity injection protocols.
Niagen is the brand name for Nicotinamide Riboside (NR) — a form of Vitamin B3 and one of the most clinically studied NAD+ precursors available. The body converts NR to NAD+ (Nicotinamide Adenine Dinucleotide), the coenzyme that drives cellular energy production, activates sirtuins for cellular repair and longevity signaling, and supports mitochondrial biogenesis. NAD+ levels decline significantly with age, and this decline is linked to reduced cellular energy, metabolic slowdown, and accelerated aging markers.
| Specification | Detail |
|---|---|
| Active ingredient | Nicotinamide Riboside (NR) — Niagen® |
| Concentration | 100 mg/mL |
| Vial size | 5 mL |
| Route | IV / IM / SQ |
| Storage | Refrigerated, protected from light |
Legere supplies licensed medical practices with a range of quantities to fit your volume needs. To get pricing, check availability, or place an order, click Request a Quote above or contact our team directly. A valid medical or pharmacy license is required to purchase prescription and injectable products.
NAD+ is produced in the body through several pathways. Nicotinamide Riboside enters the body’s primary NAD+ synthesis route — the NAMPT salvage pathway — more efficiently than many other B3 forms. Once converted to NAD+, it activates three critical cellular processes:
Sirtuin activation: Sirtuins are enzymes linked to longevity, metabolic regulation, DNA repair, and mitochondrial health. They are NAD+-dependent — they require NAD+ to function. As NAD+ declines with age, sirtuin activity falls, reducing cellular repair capacity and accelerating aging markers.
Mitochondrial biogenesis: NAD+ supports the creation of new mitochondria through SIRT1/AMPK pathways. More mitochondria means more efficient cellular energy production — relevant for patients with fatigue, metabolic decline, or poor physical recovery.
PARP activation: DNA repair enzymes (PARPs) consume NAD+. Maintaining adequate NAD+ supports the body’s ability to repair cellular DNA damage — a key mechanism in the aging process.
Legere also supplies NAD+ Injection (the active coenzyme itself) at 100mg/mL and 200mg/mL. The key difference is delivery pathway:
NAD+ Injection delivers the active coenzyme directly — fast-acting, high-impact, particularly suited for IV push protocols with visible acute effects on energy and mental clarity.
Niagen Injection (NR) provides the precursor, which the body converts to NAD+ through a more sustained metabolic process. More appropriate for subcutaneous or IM protocols and patients who want a gentler NAD+ support approach.
Both are appropriate depending on the clinical goal and patient experience being delivered.
Longevity and anti-aging practices: NAD+ optimization is central to longevity medicine. Niagen provides a more versatile delivery option — IV, IM, or SQ — than pure NAD+ IV protocols, which are limited to IV administration due to tolerability.
IV therapy and wellness clinics: Niagen can be offered as a standalone protocol or as an add-on to broader IV nutrition programs — particularly for practices whose patients want NAD+ support but prefer IM or SQ over IV infusion.
Functional and integrative medicine practices: NAD+ decline is a measurable cellular aging marker. Practices using functional testing and personalized protocols use Niagen as part of a targeted cellular health and energy program.
NAD+ Injection — For practices that offer both the precursor (Niagen/NR) and the active coenzyme (NAD+). Some protocols use NAD+ for acute IV energy infusions and Niagen for ongoing IM/SQ maintenance.
Glutathione Injection — Antioxidant protection alongside NAD+ cellular repair support — a natural longevity protocol pairing.
Alpha Lipoic Acid Injection — ALA supports mitochondrial function through complementary mechanisms to NAD+ — another natural longevity protocol pairing.
Active cancer or cancer history: NR supplementation may theoretically support cellular proliferation pathways. Use with caution and oncologist guidance in patients with active cancer or cancer history.
Pregnancy and breastfeeding: Safety in pregnancy has not been established. Consult a healthcare provider before use.
Diabetes medications: NR may affect glucose metabolism. Monitor blood sugar in patients on antidiabetic medications.
Blood pressure medications and blood thinners: Use with caution and monitor in patients on these medications.
Storage: Refrigerate, protected from light.
Prescription required. A valid medical or pharmacy license is required to purchase.
How do I order, and what quantities are available?
Contact our team directly to place an order or request a quote. Reach out for current availability, lead times, and volume pricing. A valid medical or pharmacy license is required.
What is the difference between Niagen (NR) and NAD+ injection?
NAD+ injection delivers the active coenzyme directly — fast-acting with immediate cellular availability, typically given IV. Niagen delivers Nicotinamide Riboside, which the body converts to NAD+ through a metabolic process — a more sustained approach suited for IM or SQ protocols and patients who prefer a gentler delivery method.
Why does injectable Niagen need refrigeration?
NR is sensitive to heat and moisture. Refrigeration preserves potency and ensures the concentration delivered matches what is on the label. Unlike some simpler injectables, Niagen’s stability requires cold storage throughout its shelf life.
This is a prescription injectable product. A valid medical or pharmacy license is required to purchase. For use by licensed healthcare providers only.
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