ChromaDex’s proprietary Nicotinamide Riboside at 100mg/mL raises NAD+ levels to support sirtuin activation, DNA repair, and mitochondrial health. A research-backed cornerstone of longevity injection protocols.
NAD+ declines with age — by as much as 50% between young adulthood and middle age — reducing cellular energy production and DNA repair capacity. Niagen® (Nicotinamide Riboside) is ChromaDex’s proprietary, research-backed NAD+ precursor. At 100mg/mL via injection, it raises blood NAD+ levels dose-dependently, without the niacin flush associated with other B3 forms.
| Specification | Detail |
|---|---|
| Active ingredient | Niagen® (Nicotinamide Riboside, NR) |
| Concentration | 100 mg/mL |
| Volume | 5mL per vial |
| Route | IV, IM, or SQ |
| Storage | Refrigerate; protect from light |
NAD+ biosynthesis: Enters the NAD+ salvage pathway via NRK1/NRK2 enzymes — the most direct, research-validated NR pathway available.
Sirtuin activation: NAD+ activates sirtuins, enzymes associated with mitochondrial biogenesis and cellular health maintenance.
DNA repair: NAD+ is a substrate for PARP enzymes involved in DNA repair — a key mechanism in the aging process.
No niacin flush: Unlike niacin, NR raises NAD+ without triggering the flushing response, improving patient tolerability.
Clinics offering Niagen® Injection often combine it with CoQ10 Injection, Glutathione Injection, and B12 Injections as part of a comprehensive mitochondrial health and longevity protocol.
Not recommended for patients with active cancer or history of cancer — NAD+ precursors have been studied in the context of cellular proliferation; screen carefully. Use with caution in patients on diabetes, blood pressure, or anticoagulant medications. Contraindicated in pregnancy and breastfeeding.
FAQs
Is a prescription required to order Niagen® Injection?
Yes. Niagen® Injection is a compounded Rx product dispensed exclusively to licensed healthcare providers and medical practices. It is not available for direct patient purchase.
What is the concentration and volume?
100mg/mL in a 5mL vial.
What routes of administration are available?
IV, IM, or SQ. Route and dosing protocol are determined by the ordering provider’s clinical judgment.
Why is Niagen® Injection not recommended for patients with a cancer history?
NAD⁺ precursors have been studied in the context of cellular proliferation. Out of clinical caution, this product is not recommended for patients with active cancer or a history of cancer. Providers should screen patients and consult current clinical guidance before initiating.
How does Niagen® Injection differ from GlutaTonic, which also contains a NAD⁺ precursor?
GlutaTonic contains Nicotinamide (NAM), which enters NAD⁺ synthesis via the NAMPT salvage pathway, and is delivered as a sublingual spray for daily supplementation. Niagen® Injection contains Nicotinamide Riboside (NR), a distinct compound that enters NAD⁺ synthesis via NRK1/NRK2 enzymes, delivered by injection for direct systemic availability. They complement rather than duplicate each other.
This is a compounded medication. Compounded drugs are not FDA-approved and have not been evaluated by the FDA for safety, efficacy, or quality. This product is available by prescription only and is intended for use by or on the order of a licensed healthcare provider.
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