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Polidocanol is a non-ionic detergent sclerosant widely used in cosmetic vein treatment. At a 2% concentration (20mg/mL), it damages the endothelial lining of the target vein, causing the vessel to collapse and gradually be reabsorbed by the body. It is well-established in vein care practice for treating spider veins and reticular veins, and is known for its strong tolerability profile and mild local anesthetic properties, which contribute to patient comfort during the procedure.
| Specification | Detail |
|---|---|
| Active ingredient | Polidocanol |
| Concentration | 2% (20 mg/mL) |
| Volume | 30mL multi-dose vial |
| Route | Intravariceal injection (intravascular, directly into target vein) |
| Storage | Controlled room temperature (20–25°C / 68–77°F); protect from light |
Polidocanol acts as a sclerosant by disrupting the phospholipid cell membranes of endothelial cells lining the vein wall. This causes localized cellular damage that triggers an inflammatory response, leading to fibrosis and gradual reabsorption of the treated vessel. Unlike many other sclerosants, polidocanol has mild local anesthetic properties, which help minimize injection discomfort and improve patient tolerability during the procedure.
The 2% concentration is appropriate for spider veins and reticular veins. Lower concentrations are typically used for smaller caliber vessels; clinical judgment on appropriate concentration and technique should follow current sclerotherapy guidelines and the provider’s training and experience.
Polidocanol 2% Injection is used in:
Polidocanol 2% Injection is contraindicated in patients with:
Dosing, injection technique, and treatment intervals should follow the ordering provider’s clinical training and current sclerotherapy practice guidelines. Standard sclerotherapy practice involves direct intravariceal injection into the target vessel under appropriate visualization.
As with all compounded injectables, follow applicable clinical guidelines and state prescribing requirements.
Practices offering Polidocanol Injection often round out their aesthetic menu with Glutathione Injection and Ascorbic Acid Injection for post-procedure skin support, and MesoDerm™ topical cream as a retail complement for patients focused on cosmetic body contouring.
Is a prescription required to order Polidocanol 2% Injection?
Yes. This is a compounded Rx product dispensed exclusively to licensed healthcare providers and medical practices. It is not available for direct patient purchase.
What is the concentration and volume?
2% (20mg/mL) in a 30mL multi-dose vial.
What is the route of administration for Polidocanol Injection?
Intravariceal injection, administered directly into the target vein by a trained provider. This is not a standard intravenous infusion.
What conditions contraindicate the use of Polidocanol Injection?
Polidocanol is contraindicated in patients with known hypersensitivity to the compound, acute DVT or thromboembolic disease, acute superficial thrombophlebitis, severe peripheral arterial disease, active infection or cellulitis at the injection site, or pregnancy.
What makes Polidocanol different from other sclerosants?
Polidocanol has mild local anesthetic properties alongside its sclerosing action, which helps reduce injection discomfort and improves patient tolerability compared to some alternative sclerosants.
This is a compounded medication. Compounded drugs are not FDA-approved and have not been evaluated by the FDA for safety, efficacy, or quality. This product is available by prescription only and is intended for use by or on the order of a licensed healthcare provider.
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