MesoDerm™ is a PCDC Lipo Dissolve Cream — formulated with Deoxycholic Acid, Phosphatidyl Choline, Hyaluronic Acid, Allantoin, and antioxidant vitamins for aesthetic and wellness practices. Topical body contouring, cellulite reduction, and skin rejuvenation for body, face, and neck.
MesoDerm is a topical enhancement cream formulated with the same key ingredients used in mesotherapy and lipo-dissolve injection procedures, Deoxycholic Acid and Phosphatidyl Choline in a transdermal cream that delivers these bioidentical compounds through the skin into subcutaneous fat tissue. It is designed to support localized fat reduction, improve lymphatic drainage, reduce the appearance of cellulite, and rejuvenate facial and neck skin, either as a standalone protocol or to enhance and maintain results from injectable aesthetic procedures. For aesthetic practices managing patients who want a non-injectable option, or a maintenance product between procedure sessions, MesoDerm fills a clinically meaningful gap.
| Key Ingredient | Function |
|---|---|
| Deoxycholic Acid | Facilitates fat cell breakdown and enhances lymphatic drainage |
| Phosphatidyl Choline | Bioidentical lipid compound that assists in eliminating fatty deposits |
| Hyaluronic Acid | Increases moisture, stimulates collagen synthesis, promotes tissue repair |
| Allantoin | Healing, moisturizing, soothing, and anti-irritating; keratolytic |
| Vitamins A, C, and E | Antioxidant protection and skin renewal support |
| Shea Butter | Ultra-moisturizing base; skin barrier support |
| Specification | Detail |
|---|---|
| Net weight | 4 oz (113 grams) |
| Application | 1 full pump per 6 square inches of skin |
| Frequency | 2x daily |
| Timing | Best applied after a hot bath or shower when pores are open |
Legere supplies licensed medical practices with a range of quantities to fit your volume needs. To get pricing, check availability, or place an order, click Request a Quote above or contact our team directly.
Mesotherapy and Lipo-Dissolve procedures use micro-injections of Phosphatidylcholine (PC) and Deoxycholic Acid (DC) into subcutaneous fat to remove localized fat deposits from targeted areas. These two compounds target receptors on fat cell surfaces that regulate fat storage and breakdown — DC and PC cause lipogenesis (fat storage) to decrease and lipolysis (fat breakdown) to increase, releasing fatty acids from targeted fat cells into circulation where they can be cleared through the lymphatic system.
MesoDerm uses the same active compounds in a topical format. Deoxycholic Acid and Phosphatidyl Choline are lipid-soluble — their small molecular size allows them to pass between cells and penetrate through the skin barrier into the subcutaneous layer where fat cells are located. The bioidentical nature of these compounds means they work through the same receptor mechanism as the injectable protocol, without needles.
Why hot water and open pores matter: The product sheet specifically recommends applying after a hot bath or shower. Heat increases skin permeability by temporarily expanding pores and increasing blood flow to surface tissues — both of which enhance the transdermal absorption of active compounds. This timing recommendation is clinically meaningful, not just cosmetic.
Subcutaneous fat consists of fat cells held in a matrix of fibrous proteins, polysaccharides, nutrients, and waste products — the interstitial matrix. Normally, fluids circulate through this matrix and flush it clean. With age or obesity, cellular metabolism slows and waste accumulates. As the matrix hardens, the connective tissue becomes inflexible — locking expanding fat cells in place. As fat cells expand, they push upward toward the skin surface, creating the characteristic dimpled appearance of cellulite. MesoDerm’s lymphatic drainage enhancement and fat cell breakdown support address this process at both the fat cell level and the connective tissue level.
Body: Love handles, inner thighs, hips and waist, upper arms, abdomen
Face and neck: Double chin, jowls, facial fat pockets
Any area where localized fat reduction or skin tightening is the goal
Aesthetic and med spa practices: MesoDerm is positioned as an alternative to or complement of Mesotherapy, Lipo-Dissolve, Smart-Lipo, and Kybella for practices that want to offer patients a topical option. Patients who are not candidates for injectable procedures, who want to maintain results between sessions, or who prefer a non-injectable approach are the primary audience.
Body contouring practices: For practices offering body contouring treatments, MesoDerm provides a patient home-use protocol that extends the treatment between in-office sessions and can improve overall results when used consistently.
Medical weight loss practices: As patients lose weight, targeted areas of localized fat and loose skin can be addressed with MesoDerm alongside the overall weight loss program — particularly the abdomen, flanks, and inner thighs where fat redistribution is common.
Wellness and anti-aging practices: For patients interested in skin tightening, rejuvenation, and cellulite reduction as part of a broader wellness and body care program, MesoDerm provides a clinically informed topical option with a mechanism beyond standard moisturizers.
Tretinoin Cream — For aesthetic practices combining internal and external skin renewal approaches. Tretinoin drives cellular skin renewal at the epidermal level; MesoDerm targets subcutaneous fat and deeper skin rejuvenation. A comprehensive aesthetic skin and body protocol uses both.
Zensa Numbing Cream — For practices that offer injectable procedures alongside MesoDerm as the take-home maintenance product. Zensa handles in-office numbing; MesoDerm handles the between-session home protocol.
Lipo BC Tabs — For medical weight loss practices using both oral lipotropic support and topical fat reduction. Lipo BC addresses fat metabolism systemically through liver and metabolic pathways; MesoDerm addresses localized subcutaneous fat through topical delivery.
HSN Complex Caps — For aesthetic practices addressing skin quality from both the nutritional inside and the topical outside. HSN Complex supports collagen, keratin, and skin nutrition; MesoDerm supports tissue remodeling and fat reduction at the application site.
For external use only: Apply to skin only. Avoid contact with eyes and mucous membranes.
Skin sensitivity: Patch test on a small area before full application. Some patients may experience mild warming, redness, or tingling at the application site — particularly with the first few uses — as the active compounds begin working.
Active skin conditions: Do not apply to broken skin, open wounds, active rashes, or areas with active infection or inflammation.
Pregnancy and breastfeeding: Consult a healthcare provider before use. The safety of topical Deoxycholic Acid and Phosphatidyl Choline during pregnancy has not been established.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
How do I order, and what quantities are available?
Contact our team directly to place an order or request a quote. We supply a range of quantities depending on the product — reach out for current availability, lead times, and volume pricing.
How does MesoDerm work differently from a regular moisturizer or firming cream?
Standard firming creams work on the skin surface — tightening temporarily through humectants and surface film-forming ingredients. MesoDerm’s active compounds — Deoxycholic Acid and Phosphatidyl Choline — are lipid-soluble and small enough to penetrate through the skin into the subcutaneous layer where fat cells live. They work through the same receptor mechanism as injectable Lipo-Dissolve procedures, targeting fat cell breakdown and lymphatic drainage at the tissue level rather than at the skin surface.
Is MesoDerm an alternative to Kybella or Lipo-Dissolve injections?
MesoDerm uses the same key active ingredients as injectable lipo-dissolve procedures but delivers them transdermally rather than through injection. Injections achieve higher localized concentrations more directly — they remain the gold standard for acute, targeted fat reduction. MesoDerm is better suited as a standalone option for patients who prefer a non-injectable approach, or as a maintenance and enhancement protocol between injection sessions.
How long before results are visible?
Results from consistent twice-daily use typically become visible over 4-8 weeks. Individual results vary based on the treatment area, skin thickness, baseline fat deposit volume, and consistency of use. Practices should set expectations accordingly and emphasize the importance of consistent application for meaningful outcomes.
Is MesoDerm available for private label?
Contact our team to discuss product availability and private label options for your practice.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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