Calcium Chloride Injection

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Calcium Chloride Injection: 100mg/mL Electrolyte Support

Calcium is the fifth most abundant element in the human body, essential to cardiac contractility, nerve transmission, muscle function, blood coagulation, and intracellular signaling. When calcium or mineral balance is disrupted, particularly in clinical settings involving low calcium, high potassium, or high magnesium, an injectable form provides rapid, direct correction that oral supplementation cannot achieve at the speed or concentration critical situations require.

Formula

SpecificationDetail
Active ingredientCalcium Chloride
Concentration100 mg/mL (10%)
Volume30mL vial
RouteIV only (not recommended for IM or subcutaneous use)
StorageControlled room temperature; protect from light

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Clinical Applications

Hypocalcemia: Calcium chloride is commonly administered in cases of abnormally low blood calcium levels (hypocalcemia), which can present as muscle cramps, tingling, fatigue, and in severe cases, seizures or tetany. IV delivery provides rapid correction of calcium levels, offering immediate relief while preventing further neurological or cardiac complications.

Hyperkalemia: Elevated potassium levels can cause dangerous cardiac arrhythmias. Calcium chloride stabilizes the cardiac membrane in this context, reducing the immediate risk of arrhythmia while other interventions address the underlying potassium imbalance.

Hypermagnesemia: Elevated magnesium levels can depress neuromuscular function and, in severe cases, cardiac conduction. Calcium chloride helps antagonize these effects, supporting normal cardiac and neuromuscular function.

Cardiac resuscitation and arrhythmias: Calcium chloride is used as a cardiac resuscitation adjunct, supporting heart muscle contractility during instances of arrhythmia or cardiac arrest, and in management of calcium channel blocker toxicity.

Benefits

Calcium chloride injection offers several clinical advantages over oral supplementation in acute and critical-care settings:

  • Rapid restoration of calcium homeostasis when speed of correction is clinically necessary
  • Direct electrolyte support for cardiac, nerve, and muscle function
  • Broad applicability across multiple mineral imbalance states (calcium, potassium, magnesium)
  • Supports enzyme and hormone function that depends on adequate calcium levels

Dosage

Dosage should be determined by the ordering provider based on the patient’s condition, weight, age, and clinical context.

Typical adult range: 500mg to 1,000mg IV, adjustable based on response and ongoing monitoring. Pediatric and geriatric dosing requires specific calculation; consult applicable clinical guidelines.

Administer slowly to minimize adverse reactions. Monitor the patient throughout and after administration. This product is for IV administration only and should not be given IM or subcutaneously due to risk of tissue necrosis and calcinosis.

Precautions and Drug Interactions

Severe interaction — do not use with ceftriaxone: Calcium chloride has a severe interaction with the antibiotic ceftriaxone. These two compounds should never be co-administered.

Who It’s For

  • IV therapy and wellness clinics managing mineral balance protocols
  • Emergency medicine and critical care settings requiring rapid electrolyte correction
  • Integrative and functional medicine providers supporting comprehensive IV nutrition programs

Pairs Well With

Clinics offering Calcium Chloride Injection often combine it with Magnesium Chloride, Ascorbic Acid Injection, and other electrolyte components as part of a comprehensive IV therapy protocol.

FAQ

Is a prescription required to order Calcium Chloride Injection?
Yes. Calcium Chloride Injection is a compounded Rx product dispensed exclusively to licensed healthcare providers and medical practices. It is not available for direct patient purchase.

What is the concentration and route of administration?
100mg/mL (10%), administered IV only. IM and subcutaneous administration are not recommended due to risk of tissue necrosis.

What is the most critical drug interaction providers should know about?
Calcium chloride has a severe interaction with ceftriaxone and should never be co-administered. It also has moderate interactions with approximately 48 drugs; a full medication review is essential before use.

What conditions is Calcium Chloride Injection used to manage?
It is used in the management of hypocalcemia, hyperkalemia, hypermagnesemia, hypocalcemic tetany, and as an adjunct in cardiac resuscitation and arrhythmia management.

This is a compounded medication. Compounded drugs are not FDA-approved and have not been evaluated by the FDA for safety, efficacy, or quality. This product is available by prescription only and is intended for use by or on the order of a licensed healthcare provider.

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