5-HTP Plus sublingual spray — 5-HTP, GABA, L-Carnitine, and Vitamin B6 in a fast-absorbing sublingual format — for licensed wellness, weight loss, and integrative medicine practices. Mood, sleep, and appetite support in one formula.
5-HTP Plus is a sublingual spray combining four active ingredients that support serotonin production, relaxation, energy metabolism, and appetite regulation. The sublingual delivery system — sprayed under the tongue and held for 20 seconds — bypasses first-pass liver metabolism for faster, more efficient absorption than traditional oral capsules. For wellness, weight loss, and integrative medicine practices managing patients who struggle with mood, sleep quality, stress eating, or low energy, 5-HTP Plus addresses multiple contributing factors in one convenient daily formula.
| Ingredient | Amount per serving (6 sprays / 1mL) |
|---|---|
| Vitamin B6 (as pyridoxine HCl) | 5 mg (294% DV) |
| 5-HTP | 25 mg |
| GABA | 1,500 mcg |
| L-Carnitine (as tartrate) | 100 mg |
| Servings per container | 30 |
| Other ingredients | Purified water, xylitol, stevia, malic acid, tartaric acid, citric acid, potassium sorbate, fruit flavors |
| Suggested use | 6 sprays under tongue; hold 20 seconds before swallowing |
| Private label | Available |
Legere supplies licensed medical practices with a range of quantities to fit your volume needs. To get pricing, check availability, or place an order, click Request a Quote above or contact our team directly. Private label options are available on select products.
5-HTP (5-Hydroxytryptophan) is a direct precursor to serotonin — the neurotransmitter most closely linked to mood, sleep quality, and appetite. Unlike tryptophan, which must first be converted to 5-HTP before becoming serotonin, 5-HTP enters the serotonin pathway one step closer. Higher serotonin levels support better mood, more restful sleep, and stronger satiety signals — including the release of satiety hormones that reduce the drive to keep eating.
GABA (Gamma-Aminobutyric Acid) is the brain’s primary inhibitory neurotransmitter, linked to relaxation and stress reduction. Oral GABA intake may support growth hormone release by as much as 400%, which can support lean body mass through fat breakdown and protein synthesis — making it relevant for both wellness and body composition goals.
L-Carnitine is essential for energy metabolism. It facilitates the transport of fatty acids into mitochondria where they are burned for energy, supporting both fat utilization and ATP production. A carnitine deficiency can cause irritability and fatigue — both of which undermine weight loss compliance.
Vitamin B6 is a co-factor in over 100 enzymatic reactions, including the conversion of 5-HTP to serotonin. Without adequate B6, the 5-HTP in this formula cannot complete the conversion efficiently. Including B6 at 294% DV ensures the serotonin synthesis pathway is fully supported.
Medical weight loss and GLP-1 practices: Mood-driven and stress-related eating are among the most common barriers to weight loss success. 5-HTP Plus addresses the serotonin and appetite dimension of eating behavior — a complement to the metabolic tools in a weight loss program.
Integrative and functional medicine practices: Practices addressing sleep disruption, mood imbalance, stress, and fatigue as contributing factors to poor health outcomes use 5-HTP Plus as part of a comprehensive neurotransmitter support approach.
Wellness and anti-aging practices: For patients experiencing mood changes, poor sleep, or low energy as part of the aging process, 5-HTP Plus provides targeted neurotransmitter and metabolic support in an easy-to-use daily format.
Hormone and BHRT practices: Low serotonin and poor sleep are common complaints in perimenopausal and postmenopausal women. 5-HTP Plus addresses the neurotransmitter component of these symptoms alongside hormonal interventions.
Diucaps — Diucaps supports appetite through the norepinephrine and CCK pathway; 5-HTP Plus supports it through the serotonin and satiety hormone pathway. Together they address appetite from two complementary neurotransmitter angles. Product sheets identify these as a natural pairing.
Lipo BC Tabs — Lipotropic B-vitamin fat metabolism support alongside 5-HTP Plus’s mood and appetite management. A practical combination for weight loss practices building a multi-product supplement protocol.
Stress & Adrenal Support Caps — For patients where stress is driving both poor sleep and emotional eating. Stress & Adrenal Support addresses the cortisol and adaptogen dimension; 5-HTP Plus addresses serotonin and sleep. Complementary tools for the same underlying driver.
D.N.S. Caps — Blood sugar stability support alongside neurotransmitter support. Unstable blood sugar is a common driver of mood-related eating — addressing both simultaneously strengthens the overall weight loss program.
Serotonin syndrome risk with SSRIs/SNRIs: 5-HTP increases serotonin availability. Combining it with SSRI, SNRI, MAOI, or other serotonergic medications can increase the risk of serotonin syndrome. Screen for concurrent serotonergic medications before recommending.
Carbidopa interaction: Patients taking carbidopa (used in Parkinson’s disease treatment) should avoid 5-HTP as the combination may cause skin changes and other adverse effects.
Pregnancy and breastfeeding: Not recommended. Consult a healthcare provider.
Eosinophilia-myalgia syndrome: There is historical concern about contaminated tryptophan supplements and EMS; this risk does not apply to properly manufactured 5-HTP, but sourcing from quality-controlled manufacturers is important.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
How do I order, and what quantities are available?
Contact our team directly to place an order or request a quote. We supply a range of quantities depending on the product — reach out for current availability, lead times, and volume pricing. Private label options are available.
Why is 5-HTP Plus a sublingual spray instead of a capsule?
Sublingual delivery bypasses first-pass liver metabolism — the process by which oral supplements are partially broken down before reaching the bloodstream. By absorbing through the tissue under the tongue, more of the active ingredients reach circulation faster and at higher effective levels than an equivalent oral capsule dose.
How does 5-HTP support appetite and weight loss?
Serotonin is directly linked to satiety signaling. Higher serotonin levels trigger the release of hormones that tell the brain the body is full, and suppress the neurons that drive continued eating. For patients whose overeating is driven by low mood, stress, or cravings — rather than genuine hunger — supporting serotonin production addresses the root neurotransmitter driver of that behavior.
Can 5-HTP Plus be used with appetite suppressant medications?
It can be used alongside non-serotonergic appetite suppressants like phentermine. It should not be combined with SSRIs, SNRIs, or other serotonergic medications without provider oversight due to serotonin syndrome risk.
Is private label available?
Yes. Contact our team to discuss private label options, minimum quantities, and label customization for your practice.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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