Dehydroepiandrosterone (DHEA) stands as the most abundant circulating steroid hormone in humans, functioning primarily as a precursor to both estrogens and androgens. This endogenous compound is synthesized mainly in the adrenal glands, with smaller contributions from the gonads and brain. Physicians managing hormonal imbalances can utilize DHEA supplements to support patient needs in clinical practice.
Role as a Precursor in Steroid Hormone Synthesis
DHEA converts peripherally into active sex steroids, influencing reproductive and metabolic health. Its availability directly impacts hormone equilibrium.
In the biosynthetic pathway, DHEA is metabolized to androstenedione and then to testosterone or estrone, depending on tissue-specific enzymes like aromatase. This precursor role ensures a steady supply of sex hormones beyond gonadal production. Human studies confirm DHEA’s significance in maintaining hormonal balance, particularly as gonadal function declines with age. Private label DHEA supplements provide physicians with high-purity options for targeted supplementation, addressing deficiencies without synthetic additives.
Contribution to Androgen Production in Men
In men, DHEA accounts for approximately 50% of androgen production. This contribution becomes crucial in aging populations.
Adrenal-derived DHEA supplements peripheral androgen levels, supporting muscle mass, libido, and energy. Clinical data indicate that DHEA supplementation can elevate testosterone in men with low baseline levels, though results vary. Physicians offering private label nutritional supplements can incorporate DHEA to manage andropause symptoms, ensuring bioavailable forms for optimal absorption.
Contribution to Estrogen Production in Women
In premenopausal women, DHEA contributes to over 75% of estrogen production. This underscores its dominance in female hormone dynamics.
DHEA’s conversion to estrogens occurs in peripheral tissues, bolstering ovarian output and maintaining menstrual regularity. Postmenopause, DHEA becomes the primary source of estrogens, mitigating symptoms like hot flashes. A review highlights DHEA’s role in providing ~75% of estrogens in premenopausal women. Private label DHEA supplements allow physicians to offer tailored solutions for women’s health, focusing on hormonal support.
Clinical Evidence from Human Studies
Meta-analyses affirm DHEA’s impact on sex hormone levels. Supplementation influences testosterone and estradiol effectively.
A recent meta-analysis of randomized controlled trials showed DHEA supplementation increases testosterone and estradiol in postmenopausal women, with dose-dependent effects. Supplementation on Testosterone and Estradiol. Another study emphasizes DHEA as a key source of sex steroids in both sexes. Important Source of Sex Steroids. These human trials provide physicians with evidence-based rationale for recommending DHEA supplements in practice.
Integrating DHEA Supplements in Clinical Practice
DHEA supplements fit seamlessly into physician-dispensed regimens. They address hormonal precursors directly.
Physicians should select third-party tested private label nutritional supplements to ensure safety and efficacy. Dosing typically ranges from 25–50 mg daily, adjusted for patient age, sex, and lab results. Monitoring serum levels prevents over-supplementation, as excess can lead to androgenic side effects. By stocking DHEA products for in-office or online sales, practitioners support patient hormonal health with precision and reliability.
Dr .Taylor Froiland
President of Legere Pharmaceuticals
Taylor Froiland is the president of Legere Pharmaceuticals in Scottsdale, Arizona and serves on the Board of Directors for RK Logistics Group. He also owns and operates Medmetrics Compounding Pharmacy in Chandler, Arizona, specializing in various pharmaceutical services. Taylor holds a PharmD and has expertise in compounding, medicinal chemistry, and quality control.
