Six standardized adaptogens, amino acids, and phospholipids for cortisol balance and stress response regulation — for licensed integrative, functional medicine, and wellness practices.
Stress & Adrenal Support is a specialized formula combining six clinically studied ingredients — Ashwagandha, Chinese Skullcap, Eleuthero Root, Rhodiola Rosea, L-Theanine, and Phosphatidylserine — that work together to regulate the body’s stress response, support healthy cortisol levels, and protect against the biological damage that chronic stress accumulates over time. For integrative medicine, functional medicine, BHRT, and wellness practices managing patients where stress physiology is driving fatigue, sleep disruption, weight gain, mood changes, or hormonal imbalance, Stress & Adrenal Support addresses the adrenal and neurological root of these presentations.
| Ingredient | Amount per serving (2 capsules) |
|---|---|
| Ashwagandha Extract (root, standardized to 1.5% withanolides) | 250 mg |
| Chinese Skullcap Root Extract (standardized to 30% flavonoids) | 250 mg |
| Eleuthero Root Extract (standardized to 0.8% eleutherosides) | 200 mg |
| Rhodiola Rosea Extract (standardized to 3% rosavins) | 200 mg |
| L-Theanine | 100 mg |
| Phosphatidylserine (from Sunflower) | 100 mg |
| Capsule count | 60 capsules (30 servings) |
| Other ingredients | HPMC (vegetable capsule), Rice Flour, Silicone Dioxide, Magnesium Stearate |
| Suggested use | 2 capsules daily, mid-morning, or as directed by physician |
| Private label | Available |
Legere supplies licensed medical practices with a range of quantities to fit your volume needs. To get pricing, check availability, or place an order, click Request a Quote above or contact our team directly. Private label options are available on select products.
Ashwagandha (standardized to 1.5% withanolides) is one of the most researched adaptogens for stress and cortisol management. Withanolides — the active compounds — activate GABA receptors in the brain, producing calming effects similar to the body’s own inhibitory neurotransmitter. Clinical studies show positive effects on stress assessment scales, cortisol levels, and fatigue. Ashwagandha directly supports the rebalancing of neurotransmitters disrupted by chronic stress.
Rhodiola Rosea (standardized to 3% rosavins) is an adaptogen that increases the body’s resistance to physical, chemical, and emotional stressors. It supports the nervous system, mood regulation, mental clarity, and the sleep cycle — particularly the cognitive fatigue and diminished mental performance that accompany chronic stress. Athletes use Rhodiola for recovery; general wellness patients use it for sustained mental energy under stress.
Eleuthero Root (standardized to 0.8% eleutherosides) is a classic adaptogen used to increase non-specific resistance to stressors. Eleutherosides support adrenal function, immune competence, and physical endurance — making Eleuthero particularly relevant for patients whose stress manifests as physical fatigue and reduced resilience.
Chinese Skullcap Root (standardized to 30% flavonoids) contains antioxidant flavonoids that downregulate oxidative stress in tissues including the liver — one of the primary organs affected by chronic cortisol elevation. Skullcap’s antioxidant activity addresses the tissue-level damage that chronic stress accumulates beyond the adrenal and neurological effects.
L-Theanine is a naturally occurring amino acid found in green tea that promotes relaxation without sedation by reducing excitatory neurotransmitter activity and supporting GABA, dopamine, and serotonin. It is particularly effective at quieting the racing mind and reducing the anxiety-driven overthinking pattern that accompanies acute and chronic stress.
Phosphatidylserine (from Sunflower) is a phospholipid that is a structural component of cell membranes — particularly in brain cells — and plays a direct role in cortisol regulation. Research shows it can reduce cortisol output in response to stress. It has also been specifically studied for its ability to reduce the cortisol spike associated with overtraining in athletes.
The product sheet lists the consequences chronic stress creates — and these are the clinical presentations that bring patients to integrative and functional medicine practices in the first place: anxiety, depression, sleep disorders, obesity, diabetes, osteoporosis, GI issues, sexual dysfunction, and cardiovascular disease. Stress & Adrenal Support addresses the physiological root — chronic cortisol elevation and adrenal dysregulation — rather than managing symptoms in isolation.
Integrative and functional medicine practices: The primary audience. Practices that assess adrenal function, cortisol patterns, and stress physiology as part of a root-cause workup use Stress & Adrenal Support as their go-to adaptogen formula for patients with HPA axis dysregulation.
BHRT and hormone optimization practices: Chronic stress depletes DHEA — the adrenal hormone precursor — and elevates cortisol, which competes with and disrupts sex hormone function. Practices managing hormone balance that include adrenal health in the protocol use Stress & Adrenal Support alongside DHEA and hormone therapy.
Medical weight loss practices: Cortisol drives visceral fat accumulation, increases appetite for calorie-dense foods, promotes insulin resistance, and disrupts sleep — all of which undermine weight loss. For patients where stress is a driver of weight gain or a barrier to weight loss, addressing cortisol directly is part of the clinical strategy.
Wellness and concierge medicine practices: Executive and high-performance patients with demanding schedules use adaptogenic support proactively — maintaining cognitive performance, stress resilience, and adrenal health rather than waiting until burnout drives the conversation.
DHEA 25mg Capsules — Chronic stress depletes DHEA. Stress & Adrenal Support addresses the cortisol side of the adrenal hormone picture; DHEA caps address the depleted precursor hormone side. Together they provide comprehensive adrenal support.
D.N.S. Caps — Cortisol elevates blood sugar through gluconeogenesis, contributing to insulin resistance. D.N.S. supports blood sugar metabolism; Stress & Adrenal Support addresses the cortisol driver. A relevant combination for patients with stress-related metabolic dysfunction.
5-HTP Plus — Chronic stress depletes serotonin. 5-HTP Plus supports serotonin precursor availability; Stress & Adrenal Support manages the cortisol-driven adrenal response. For patients where both mood and stress physiology are part of the clinical picture.
Kato Plus Caps — Chronic stress increases urinary magnesium excretion. Stress & Adrenal Support addresses the stress response itself; Kato Plus replenishes the magnesium being lost through that stress response.
Thyroid conditions: Ashwagandha may affect thyroid hormone levels. Patients with thyroid conditions or on thyroid medication should discuss with their provider before use and monitor thyroid function.
Autoimmune conditions: Some adaptogens — including Ashwagandha and Eleuthero — can stimulate immune activity. Patients with autoimmune conditions should discuss with their provider before use.
Sedative medications: L-Theanine promotes relaxation through GABAergic pathways. Combining with sedative medications (benzodiazepines, sleep medications) may produce additive CNS depression effects.
Pregnancy and breastfeeding: Not recommended. Several ingredients have not been adequately studied in pregnancy. Consult a healthcare provider.
Phosphatidylserine and blood thinners: Phosphatidylserine may have mild anticoagulant effects at higher doses. Patients on blood thinners should notify their provider.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
How do I order, and what quantities are available?
Contact our team directly to place an order or request a quote. We supply a range of quantities depending on the product — reach out for current availability, lead times, and volume pricing. Private label options are available.
What is an adaptogen and how does it help with stress?
Adaptogens are a specific class of botanical compounds that help the body adapt to physical, chemical, and emotional stressors — increasing non-specific resilience rather than producing a single targeted pharmacological effect. They work primarily through the HPA (hypothalamic-pituitary-adrenal) axis, supporting a more balanced cortisol response and a faster return to baseline after a stressor. Unlike sedatives, which suppress the nervous system, adaptogens help regulate it.
Why are the extracts in this formula standardized?
Standardization means the concentration of the active compounds — withanolides in Ashwagandha, rosavins in Rhodiola, eleutherosides in Eleuthero, flavonoids in Skullcap — is guaranteed at a specific percentage. Non-standardized botanical extracts have highly variable potency depending on growing conditions, harvest time, and processing. Standardized extracts ensure the dose on the label reflects what is clinically active, making dosing consistent and results reproducible.
How does Stress & Adrenal Support relate to BHRT protocols?
Chronic cortisol elevation competes with and suppresses sex hormone production — it is a significant driver of hormonal imbalance in perimenopausal women and men with declining testosterone. Addressing the adrenal stress physiology through adaptogenic support can improve the effectiveness of hormone therapy by reducing the cortisol interference that blunts hormone signaling. It also protects DHEA — the adrenal precursor to sex hormones — from being sacrificed to cortisol production.
Is private label available?
Yes. Contact our team to discuss private label options, minimum quantities, and label customization for your practice.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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