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Boswella™ is the gum resin extracted from the Boswellia serrata plant from India. Boswellic acids are used in traditional Ayurvedic medicine in India and African countries for the treatment of a variety of conditions.
New research into the Boswellia resin has shown that boswellic acids are powerful inhibitors of pro-inflammatory molecules. Boswellia is able to inhibit the enzyme 5-LOX, intervening at the cellular level to block its unwanted effects. Inhibiting this enzyme restricts synthesis of inflammatory signaling molecules called leukotrienes.
Most NSAIDs target inflammation by attempting to inhibit the enzyme COX-2, however they also block the enzyme COX-1, which is needed to maintain a healthy stomach lining. This is just one of the causes of NSAID toxicity, contributing to the development of ulcers and kidney problems. These side effects are considered so serious that the FDA now requires a warning to be placed on NSAIDs and COX inhibitors.
While Boswellic acids inhibit leukotriene synthesis via 5-LOX inhibition, there is no effect on COX activities. This explains why, unlike NSAIDs, Boswellia has no undesirable side effects. Boswellia is completely non-toxic and does not require a prescription.
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