Featuring the Fat Blasting Power of LIPOTROPICS, cAMP, & AMPK
LIPO-BC – lipotropics
Lipotropic nutrients such as those found in LIPO-BC belong to a class of substances that play important roles in the body’s use of fat. Through their involvement in lipid metabolism, lipotropics help maintain liver function and promote fat excretion. “it breaks fat down for use as an energy source. This action makes it valuable in preventing conditions like fatty liver or excess fat in the blood.” (Elsawy et al, 2014)
A lipotropic nutrient promotes or encourages the export of fat from the liver. Lipotropics are necessary for maintenance of a healthy liver, and for burning the exported fat for additional energy. Without lipotropics, fats and bile can become trapped in the liver, causing severe problems such as cirrhosis and blocking fat metabolism.
Inositol helps to metabolize fat and aid in the redistribution of body fat. Inositol has been shown in studies to help prevent increases in fatty acids and total cholesterol in the liver. A deficiency of inositol can result in an accumulation of triglycerides in the liver, which impairs normal liver function and can lead to weight gain.
Choline is an essential nutrient that is related to the B vitamins. It is responsible for lipid (fat) metabolism and transport and has other jobs in the body related to cell membrane structure and other functions. Without choline, fats can become trapped in the liver and block metabolic functions.
These ingredients are combined with B-Vitamins which play an important role in fatty acid synthesis, and energy production, and vitamin C which has been shown to help reduce cortisol levels post-exercise.
My-B-Tabs – AMPK
Adenosine monophosphate (AMP) is a naturally occurring cellular metabolite and is one of the four purine nucleotides responsible for protein synthesis. It is also a key component in certain enzyme reactions necessary for proper fat and carbohydrate metabolism. AMP is beneficial for correcting low energy production due to mitochondrial dysfunction by increasing AMPK activity, a crucial regulator of cellular metabolism. AMPK activation has been shown to help reduce fat storage and triglyceride production while increasing fat burning and glucose uptake. When AMPK activity is impaired, glucose and fat begin to accumulate, leading to conditions such as increased belly fat, elevated blood sugar, insulin resistance, and high cholesterol.
The net effects of AMPK activation closely resemble those of calorie restriction and vigorous exercise. This is because both calorie restriction and vigorous exercise activate AMPK in response to energy needs that exceed supply.
Research has shown that targeted activation of AMPK can have a variety of health benefits. Increased AMPK activation has been shown to help reduce fat storage (especially dangerous belly fat), increase insulin sensitivity (to lower blood glucose), reduce cholesterol/triglyceride production, and producing other beneficial effects. Because AMPK activity declines with age, increasing AMPK has also proved promising for preventing, and possibly even reversing, symptoms of aging – potentially increasing longevity.
The presence of adenosine monophosphate (My-B-Tabs) leads to an increase in AMPK activity by approximately 5-fold, however AMP also plays an important role in regulating the level of phosphorylation of AMPK. “An increased AMP to ATP ratio leads to […] increased phosphorylation and decreased dephosphorylation of AMPK. The phosphorylation of AMPK results in activation by at least 100-fold.” This means that a relatively small increase in AMP can result in a dramatic increase of AMPK activity.
NUTRILEAN – cAMP
The ingredients found in NUTRILEAN (forskolin + acetyl-l-carnitine) have been identified for their ability to increase cAMP. This leads to many of the same desirable metabolic changes that occur during fasting.
The primary impact of cAMP is to facilitate and promote the mobilization of glucose and fatty acids. Cyclic adenosine monophosphate (cAMP) is an important messenger for many biological processes including metabolism. cAMP promotes breakdown of stored fats, regulates thermogenic responses to food, increases the body’s metabolic rate, and increases the utilization of fat.
“Typically, an increase in cAMP levels leads to subsequent activation of protein kinase. Protein kinase has been shown to activate the hormone-sensitive lipase that is involved in the breakdown of triglycerides, known as building blocks of fatty tissue” (Berdeaux & Stewart, 2012)..
In addition to promoting fat burning, cAMP encourages development of lean muscle. Researchers have demonstrated that “cAMP participates in muscle development and regeneration mediated by muscle precursor cells” (Berdeaux & Stewart, 2012).
In the muscles, increasing cAMP results in increased activity of glycolysis, an ATP-producing process that begins with the breakdown of glucose. Studies have found that low glycolytic activity is associated with reduced muscle size (Tixier et al, 2013).
Elsawy, G., Abdelrahman, O., & Hamza, A. (2014). Effect of choline supplementation on rapid weight loss and biochemical variables among female taekwondo and judo athletes. Journal of human kinetics, 40, 77–82. https://doi.org/10.2478/hukin-2014-0009
Berdeaux, R., & Stewart, R. (2012). cAMP signaling in skeletal muscle adaptation: hypertrophy, metabolism, and regeneration. American journal of physiology. Endocrinology and metabolism, 303(1), E1–E17. https://doi.org/10.1152/ajpendo.00555.2011
Tixier, V., et al. (2013). Glycolysis supports embryonic muscle growth by promoting myoblast fusion. PNAS 110 (47) 18982-18987